报告题目：Oxidative Cross-Coupling with Hydrogen Evolution Reactions

报 告 人：雷爱文  教授

报告时间：2022年3月7日  上午9点

报告地点：攀枝花学院办公楼4楼附楼会议室

主讲人简介：

雷爱文，武汉大学化学与分子科学学院二级教授，高等研究院副院长，国务院政府特殊津贴专家, 国家“万人计划”科技创新领军人才(2017)，国家中青年科技创新领军人才(2015)，英国皇家化学学会会士(2015)，长江学者特聘教授(2014)，国家杰出青年基金获得者(2010)。目前担任中国化学会催化委员会均相催化专业委员会副主任委员、中国化学会有机化学专业委员会委员，中国化学会物理有机专业委员会委员，Chem顾问编委、Chemical Reviews顾问编委、ACS Catalysis 顾问编委，Chemistry-An Asian Journal、Chinese Chemical Letters编委，ChemSusChem国际顾问编委等。研究领域是发展高选择性的，绿色合成方法学。不同于传统利用亲核试剂和亲电试剂偶联构建化合物的思路，发展了利用两个不同亲核试剂构建化合物的新思路。充分应用到各种C-C，C-N，C-S等成键反应中。近年来，聚焦于利用光、电发展绿色合成化学，合成并利用纳米催化，发展电催化设备等，寻求对高值化工产品，医药活性分子，染料分子等绿色创制与升级提供解决方案。到目前为止发表论文400余篇，影响因子大于12的科研论文100余篇。到目前论文总引用次数近3万余次，2016-2021年连续入选Thomson Reuters和Elsevier的全球“高被引科学家”。

Abstract：

Employment of R1-H/R2-H cross coupling has been recognized as powerful and straightforward tool for the construction of C-C/C-X bonds. Over the past decades, significant progress has been made in this field. However, a sacrificial chemical oxidant is always required for the driving force of R1-H/R2-H cross coupling, resulting in a mass of undesired byproducts. A more dream reaction pathway is to achieve oxidative R1-H/R2-H cross-coupling with hydrogen evolution without external oxidants (ΔGrxn>0). Integration of photocatalysis and hydrogen evolution catalysis has emerged as a promising strategy for achieving oxidative coupling with hydrogen evolution (ΔGrxn<0). Electricity has also emerged as a good alternative to chemical oxidant to drive chemical reaction (ΔGrxn<0). Anodic oxidation along with the cathodic proton reduction (H2 evolution) has been widely used in organic synthesis. Compared with classical synthetic methods, these dream transformations feature mild conditions, high atom economy, and elimination of oxidants.